CANCELLED - MCDB Seminar Series.
Due to circumstances beyond our control, the MCDB seminar tomorrow has been cancelled. We hope to reschedule Dr. Serpe in the future. Thank you for your understanding.
Mihaela Serpe, National Institute of Child Health and Human Development. "Neto Controls Assembly and Maintenance of Synapses at the Drosophila NMJ"
Synapse development is a highly orchestrated process that requires bidirectional
communication between two synaptic partners across the synaptic cleft. We use
the Drosophila NMJ model system to determine the mechanisms of ionotropic
glutamate receptors (iGluRs) recruitment and stabilization at the synapses. We
have identified the Drosophila neto as a novel, essential gene required for
clustering of iGluRs at the NMJ. Neto is a transmembrane protein that clusters in
concert with iGluRs and directly controls synapse formation at the Drosophila
NMJ. Neto also appears to mediate formation of a trans-synaptic complex
between postsynaptic iGluRs and presynaptic BMP signaling complexes. We
show that BMP signaling complexes are recruited and stabilized at presynaptic
terminals in response to postsynaptic type-A glutamate receptor activity. In turn,
presynaptic BMP complexes mediate stable incorporation of type-A glutamate
receptors at synapses and organization of postsynaptic densities.