GCDB Seminar Series: "Pattern formation and regeneration in a single cell." Wallace Marshall, University of California - San Francisco.
The mechanisms by which cells form complex structures is an enduring mystery in cell biology. One approach to this question is to study the development of cellular structure as though the cell was an embryo, allowing concepts of developmental biology to be applied to individual cells. A classical model organism for studying the embryology of cells is Stentor coeruleus, a giant ciliate whose complex structure, large size, and amazing wound-healing capability made it a favorite organism of study 100 years ago. However, despite a century of surgical studies on Stentor morphogenesis and regeneration, it was never developed as a molecular model system. We have now sequenced the Stentor genome and developed methods for perturbing gene function in Stentor, allowing us to begin probing the mechanisms by which the cell can sense perturbations in structure and direct morphogenetic programs to correct them. I will present our current efforts to use unbiased methods for exploring the genomic program of regeneration in this amazing cell.
- Thursday February 16, 2017 04:00 PM
- Thursday February 16, 2017 05:00 PM
- Myers Hall 130
- IU Biology Seminars
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- Host: Mike Lynch
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- Refreshments served prior to seminar.