Experiments in particle physics have led to a consistent theory of the origins of our world - but only up to a certain point. In addition, particle physics - physics of the very small - is intimately connected to cosmology – physics of the very big. Cosmological observations also point to the need for a new physical theory. In this colloquium, I will trace out the path from where we are now to where we need to go in order to take the next steps towards solving these mysteries. This journey requires global-scale projects. I will describe how the international particle-physics community is developing plans for creating such facilities. I will also discuss some of the obstacles for the U.S. to compete for these big science projects. A new framework may be needed to overcome these obstacles.